Shopping Cart
- Remove All
Your shopping cart is currently empty
UCM 608
🥰Excellent
Catalog No. T22499Cas No. 151889-03-1
Alias UCM608, 2-Phenylmelatonin
UCM 608 (2-Phenylmelatonin) is an antagonist of melatonin-induced contractile responses at low concentrations and induces an increase in GDP-GTP exchange.
UCM 608
🥰Excellent
Purity: 98.88%
Catalog No. T22499Alias UCM608, 2-PhenylmelatoninCas No. 151889-03-1
UCM 608 (2-Phenylmelatonin) is an antagonist of melatonin-induced contractile responses at low concentrations and induces an increase in GDP-GTP exchange.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $46 | In Stock | |
| 5 mg | $72 | In Stock | |
| 10 mg | $98 | In Stock | |
| 25 mg | $168 | In Stock | |
| 50 mg | $247 | In Stock |
Bulk & Custom
Add to Cart
Questions
View MoreInhibitors Related to "UCM 608"
6-Chloromelatonin
T2253063762-74-3In house
6-Chloromelatonin is a potent melatonin receptor agonist, a 5-methoxyindole compound that competes for presynaptic melatonin receptor sites in the rabbit retina, inhibiting the calcium-dependent release of [3H]dopamine with higher metabolic stability than melatonin. Chloromelatonin competitively binds to [3H]melatonin at MT2 receptors (pKi=9.77) and may be used to study insomnia and sleep disorders associated with depression.
- $350
Size
QTY
Ramelteon
TAK-375
T1463196597-26-9
Ramelteon (TAK-375) is a Melatonin Receptor Agonist. The mechanism of action of ramelteon is as a Melatonin Receptor Agonist.
- $37
Size
QTY
N-ACETYLTRYPTAMINE
T86001016-47-3
N-ACETYLTRYPTAMINE is a partial agonist for melatonin receptors in the retina. Also used for determination of serotonin N-acetyl transferase.
- $37
Size
QTY
Luzindole
N-0774
T15795117946-91-5
Luzindole (N-0774) is a selective melatonin receptor antagonist that inhibits experimental autoimmune encephalomyelitis and exhibits antidepressant-like activity. It preferentially targets MT2 (Mel1b) over MT1 (Mel1a), with Ki values of 10.2 nM for human MT2 and 158 nM for MT1.
- $47
Size
QTY
4-P-PDOT
Cited
4-phenyl-2- propionamidotetralin
T14042134865-74-0
4-P-PDOT (4-phenyl-2- propionamidotetralin) is a potent, selective and affinity Melatonin receptor (MT2) antagonist.
- $31
Size
QTY
CitedAgomelatine
Valdoxan, Thymanax, S-20098
T1445138112-76-2
Agomelatine (Valdoxan) is structurally closely related to melatonin. Agomelatine is a potent agonist at melatonin receptors and an antagonist at serotonin-2C (5-HT2C) receptors, tested in an animal model of depression.
- $57
Size
QTY
Melatonin Cited
N-Acetyl-5-methoxytryptamine, Melatonine
T165973-31-4
Melatonin (Melatonine) is a natural hormone secreted by the pineal gland that activates melatonin receptors. Melatonin is a hormone that regulates the biological clock and also has antioxidant and anti-inflammatory activities.
ApoptosisAutophagyCaMKEndogenous MetaboliteEstrogen/progestogen ReceptorGlutathione PeroxidaseMelatonin ReceptorMitophagyROR
- $31
Size
QTY
CitedACH-000143
T91932225836-30-4
ACH-000143 have been identified as a novel agonist of the melatonin receptors MT1 and MT2.
- $48
Size
QTY
Tasimelteon
VEC-162, BMS-214778
T3495609799-22-6
Tasimelteon (BMS-214778) is a melatonin receptor agonist that is used for the treatment of non-24 hour sleep-wake disorder in blind individuals.
- $38
Size
QTY
2-Iodomelatonin
T1007393515-00-5In house
2-Iodomelatonin is a potent agonist of melatonin receptor 1 (MT1) with a Ki value of 28 pM, exhibiting over 5-fold selectivity for MT1 compared to MT2. It can be used to identify, characterize, and localize melatonin binding sites in the brain and peripheral tissues.
- $38
Size
QTY
Select Batch
Purity:98.88%
Contact us for more batch information
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | UCM 608 (2-Phenylmelatonin) is an antagonist of melatonin-induced contractile responses at low concentrations and induces an increase in GDP-GTP exchange. |
| Targets&IC50 | MT1 receptor:10.7 (pKi), MT2 receptor:10.4 (pKi) |
| In vitro | UCM 608 is an agonist with high affinity for melatonin membrane receptors. Its pKi values for MT1 and MT2 receptors are 10.7 and 10.4, respectively. [1] |
| Alias | UCM608, 2-Phenylmelatonin |
| Molecular Weight | 308.37 |
| Formula | C19H20N2O2 |
| Cas No. | 151889-03-1 |
| Smiles | O=C(NCCC=1C=2C=C(OC)C=CC2NC1C=3C=CC=CC3)C |
| Relative Density. | 1.172g/cm3 |
Storage & Solubility Information
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 20.00 mg/mL (64.86 mM), Sonication is recommended. Ethanol: 20.00 mg/mL (64.86 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO/Ethanol
| |||||||||||||||||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Preview
Related Tags: buy UCM 608 | purchase UCM 608 | UCM 608 cost | order UCM 608 | UCM 608 chemical structure | UCM 608 in vitro | UCM 608 formula | UCM 608 molecular weight
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.